Nagalase and autism – understanding the science and potential treatments

Autism is a developmental disorder that affects communication and social interaction skills. The exact cause of autism is not yet fully understood, but research has suggested that genetics, environmental factors, and immune system dysfunction may play a role.

One enzyme that has recently been studied in relation to autism is called Nagalase (N-acetylgalactosaminidase) an enzyme that can inhibit the body’s natural immune response, and some studies have suggested a link between elevated levels of nagalase and autism.

In this essay, we will explore the relationship between nagalase and autism, and discuss the potential implications of this research.

In healthy people with a fully functioning immune system, a protein called

Glyco Protein derived activating factor (VDTP) is being constantly produced, which activates macrophages – white blood cells that are responsible for killing cancer cells and viruses.

These findings suggest that the reason Nagalase is so dangerous to our immune responses, is that it can break down our vital VDTP, inhibiting the activation of macrophages and weakening the body’s immune response.

High levels of nagalase have been observed in various diseases, including cancer, chronic fatigue syndrome, and autism. And so this is where testing can help us, if we can determine the levels of Nagalase in everyone, can we determine the levels of disease within us that are causing us harm and therefore take measures to rectify it?

Please see this post for full details on the vital role of VDTP in the immune system.

We’ve found that the new Nagalase Rapid home testing kits from BioRemedix are a very good solution. The kit comes with everything required. A lancet (small needle) is included to prick the finger to obtain a tiny blood sample, which makes it far quicker and easy to use than the old Nagalase tests. With these new rapid home test kits there is no need for stressful hospital visits, scary big needles and lengthy waits for the results. With these new Rapid home test kits you can test for Nagalase levels in the comfort of you own home and see the results for yourself in less than 15 minutes. Whilst the tests are said to be and amazing 98% reliable, which is the highest we have ever seen.

Please see below




Nagalase Rapid Test Kit instructions


To contact Bio Remedix please click here: [email protected]

Now, let’s talk Nagalase…

A study published in the Journal of International Medical Research in 2016 found that children with autism had significantly higher levels of nagalase compared to typical child development. Another study published in the Journal of Neuroinflammation in 2017 found that children with autism had higher levels of nagalase in their cerebrospinal fluid compared to other children who are not on the autism spectrum.

These findings suggest that nagalase may play a role in the development and/or progression of autism.

Despite the suggestive evidence linking nagalase and autism, more research is needed to fully understand the relationship between the two. For example, it is still unclear whether elevated nagalase levels are a cause, or a consequence of autism, or whether it is a secondary effect of other underlying factors.

Moreover, it is important to note that not all individuals with autism have elevated levels of nagalase. In fact, some studies have found no significant difference in nagalase levels between individuals with autism and typically developing controls. This suggests that elevated nagalase levels may only be present in a subset of individuals with autism, and that other factors may be at play in the development of the disorder.

Despite the uncertainties surrounding the relationship between nagalase and autism, the potential implications of this research are significant. If nagalase is found to play a causal role in the development of autism, it could pave the way for new treatments that target the enzyme.

For example, researchers have already developed a VDTP -based treatment for cancer that involves injecting patients with VDTP to activate their immune system. Similar treatments could potentially be developed for autism. To target nagalase, to restore the immune function and reduce the symptoms.

In conclusion

Nagalase is an enzyme that can inhibit the body’s natural immune response, and some studies have suggested a link between elevated levels of nagalase and autism. However, more research is needed to fully understand the relationship between nagalase and autism, and to develop potential treatments based on this information. Despite the uncertainties, the potential implications of this research are significant, and could ultimately lead to new treatments for individuals with autism.

See below for further details…

The Significance of Nagalase in Autism Spectrum Disorder: A Comprehensive Analysis of its Mechanisms and Therapeutic Implications.

Autism Spectrum Disorder (ASD) is characterized by symptoms such as repetitive behaviors, restricted interests, and a lack of social and language skills. The underlying causes of ASDs are multifactorial, including various biochemical processes such as oxidative stressmitochondrial dysfunctionintestinal dysbiosis, and immune abnormalities.

Studies have indicated that immune system anomalies are frequently described by autistic individuals and their family members. Furthermore, a recent hypothesis suggests that certain immune factors can disrupt the normal functions of microglia cells, which are responsible for directing neuronal migration and pruning processes.

Nagalase is observed to be elevated in numerous viral-mediated acute and chronic disease states, including ASDs. High levels of N-acetylgalactosaminidase (Nagalase) have been observed in the blood of children with ASDs, which precludes macrophage activation and may play a role in the pathogenesis of ASDs.

Nagalase levels in children with ASDs may reflect ongoing viral latency (when virus is present in the body but exists in a resting state without producing more viruses) from in the uterus (in utero) or the early postnatal period. Second-generation VDTP has been shown to normalize the experiential differences of dysregulated gene expression of the endocannabinoid system in patients’ BMDMs (Bone marrow-derived macrophage) in a clinical study of autistic individuals.

Given the immune dysregulations observed in ASDs, hematopoietic stem cells (HSCs) represent a potential target for immune-directed interventions. HSCs are useful in controlling chronic inflammation and in restoring immunological balance, which could be beneficial in treating ASDs. Future studies involving assessments of intelligence, cognition, and behavior of autistic patients, along with biomolecular evidence pointing to complex gene-environmental interactions, may provide more insights into the mechanisms and therapeutic implications of Nagalase in ASDs.

Understanding Nagalase and its link to Autism

Nagalase is an enzyme that is produced by cancer cells and viruses, and it has been found to be elevated in individuals with autism. Nagalase is responsible for deglycosylating the Glyco Protein, which is essential for activating the immune system. The reduction of Gc protein levels due to nagalase activity can lead to immune suppression, which has been linked to the development of autism.

A study conducted by Bradstreet et al. in 2012 found that most individuals with autism had significantly higher levels of nagalase than individuals without autism. These findings suggest that nagalase may play a role in the development of autism.

The link between nagalase and autism has led to the development of treatment options aimed at reducing nagalase levels in individuals with autism. One such treatment is the use of VDTP, which is responsible for activating macrophages in the immune system. VDTP treatment has been found to ameliorate autistic symptoms in some individuals. Dosing of VDTPis recommended based on previously reported response curves adjusted by the treating clinician for age, weight, and nagalase levels. While VDTP treatment has shown promising results, further research is needed to fully understand its effectiveness in reducing nagalase levels in individuals with autism.

The connection between nagalase and autism has led to increased interest in measuring nagalase levels in individuals with autism. The nagalase level in the blood can be measured to assess immune system function. For a patient under treatment, checking nagalase levels can be used to monitor the effectiveness of treatment and adjust dosing if necessary. These measurements may provide valuable information for healthcare professionals in developing effective treatment plans for individuals with autism.

Please see this article for more information on the latest easy to use Home Nagalase test kits that are 98% sensitive and accurate

For more information please contact: [email protected]



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