Bacopa monniera, more commonly known as Brahmi, is well known in traditional Ayurvedic medicine. It is a creeping plant found in damp, marshy regions throughout India. Of all Indian herbal therapies, Brahmi was and still IS, considered to be the premier herb for treating brain problems and age-related mental decline, as well as for improving learning processes and memory.
The herb Brahmi is exceptional because it is non-toxic and suitable for all body types. In particular, Indian physicians found that the nervous system benefits most from the effects of Brahmi, and this was learnt through the success of ancient medical practices over the last three thousand years.
They discovered that Brahmi contains two main active ingredients, Bacosides A and B. In the brain, the effects of these substances were to increase cell metabolism and new protein synthesis, specifically for cells in the regions of the brain associated with long term recall where learning and memory are concentrated.
The effects of Brahmi can be of benefit to anyone wishing to stimulate their powers of recall and concentration. Although Brahmi has been shown to be helpful in treating age-related mental deterioration and concentration difficulties due to stress, it may be also beneficial where there is no health condition, but only the desire to improve thinking power. It is suitable for an elderly person hoping to regain memory.
The benefit of Brahmi on Demntia
A wide variety of neuroprotective herbs have been reported in Ayurveda. Brahmi, Bacopa monnieri is a nootropic ayurvedic herb known to be effective in neurological disorders from ancient times. Numerous approaches including natural and synthetic compounds have been applied against Alzheimer’s disease. Amyloid-β and Tau are the hallmarks proteins of several neuronal dysfunctions resulting in Alzheimer’s disease. Tau is a microtubule-associated protein known to be involved in progression of Alzheimer’s disease. The generation of reaction oxygen species, increased neuroinflammation and neurotoxicity are the major physiological dysfunctions associated with Tau aggregates, which leads to dementia and behavioural deficits.
Bacoside A, Bacoside B, Bacosaponins, Betulinic acid, etc; are the bioactive component of Brahmi belonging to various chemical families. Each chemical component known have its significant role in neuroprotection. The neuroprotective properties of Brahmi and its bioactive components including reduction of ROS, neuroinflammation, aggregation inhibition of Amyloid-β and improvement of cognitive and learning behaviour.
Here on the basis of earlier studies, we hypothesize the inhibitory role of Brahmi against Tau-mediated toxicity. The overall studies have concluded that Brahmi can be used as a lead formulation for treatment of Alzheimer’s disease and other neurological disorders.
Researchers are coming by evidence that herbs like Brahmi, associated with the ayurveda system of medicine, can help ward off Alzheimer’s disease and preserve one’s mental faculties. Although what exactly causes Alzheimer’s is not known, sufferers experience inflammation of the brain, deposits of beta amyloid, traces of heavy metals and signs of oxidative stress.
Brahmi, a semi-aquatic plant, acts on all of these, said Con Stough, director of the National Institute of Complementary Medicine (NICM) involved in trials underway at Swinburne University of Technology Brain Sciences Institute (BSI) said: “It has an anti-inflammatory effect, is an antioxidant and collates and removes heavy metals and beta amyloid.”
Two trials with a brahmi extract called CDRI08, conducted over 90 days, have shown improvements in working memory, particularly spatial memory accuracy.
Dosages in capsules or tablets range from 600 to 3,000 mgs with or without additives of ginkgo, lecithin and fish oil.
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