THE INCREASING NEED FOR GCMAF IMMUNOTHERAPY

BREAKING NEWS: After over a decade of backlash against it we are now seeing further recognition emerge as to the great advantages of GcMAF (Gc Protein Macrophage activating Factor), also known as Vitamin D Transport/Binding Protein which is naturally produced by the body and is the main trigger to activating Macrophages, the main fighter cells and front line defence of the entire immune system.

The NCBI (National Center for Biotechnology Information) advances science and health by providing access to biomedical and genomic information and is a central reference point for government research. It is also part of the U.S. National Library of Medicine and it is here that the article describes the many benefits of GcMAF, not only in combatting COVID-19, but also for other immune diseases.
The  NCBI article entitled Potential role of GcMAF in suppressing the severity of COVID-19-induced immune responses: Lesson learned from HIV was first published on Science Direct this month. With so much news and concern over the pandemic Covid-19, this is surely good news for everyone, as according to the article:

“It is now well known that DBP Gc-globulin plays a crucial role in immune system regulation as a primary defense against infection.  In addition to the storage and transport of active vitamin D3, GcMAF’s effects include macrophage modulation, osteoclast activation, facilitation of neutrophil chemotaxis mediated by C5 derived peptide, superoxide activity, scavenging of circulating G-actin, anti-angiogenetic and anti-tumor properties.

Thus, this multifunctional protein, released into the blood stream, acts as a systemic immune modulator without pro-inflammatory activities. This means that any function impairment of Gc-globulin could result in a state of both immunosuppression and uncontrolled inflammation, just like in severe COVID-19. Interestingly, HIV viremia was associated with higher level of biomarkers of inflammation (measured by IL-6), monocyte activation (soluble CD14), and coagulation (D-dimer), leading to increased mortality, as compared with uninfected people. Meanwhile, in COVID-19 patients, in addition to the reduced peripheral lymphocyte counts, mainly CD4⁺ T and CD8⁺ T cells, there were found significant high levels of pro-inflammatory cytokines and chemokines.

Indeed, GcMAF is not only a simple potent activator for macrophages, but more specifically is able to turn macrophage activity on at the sites of infection/inflammation and then to induce their apoptosis by upregulating caspase activity via the p38 and JNK1/2 pathways when no longer needed.

Post-mortem lung observations of patients died of COVID-19 showed the presence of mononuclear cells and macrophages infiltrating air spaces by autopsy 

And so they highlight the need for further research:

“Although the administration of GcMAF is a yet an unapproved therapy, data from previous studies and clinical practice reported its effectiveness in the treatment of many pathologies such as HIV infection ^[55] and other infectious diseases ^[53], some types of cancer juvenile osteopetrosis ^[61], immunological (systemic erythematous lupus) ^[62] and neurological (multiple sclerosis, autism) diseases ^{[57], [63], [64]}. In the same conditions, it was found an inverse correlation between the MAF precursor activity and serum levels of nagalase (reference ranges from 0,32 to 0,65–0,95 nM/min/ng), therefore showing to be other than pathogenicity or cancer biomarkers, also good prognosticators of illness and response to therapy 

However, it’s clear that only well-designed clinical trials will be able to properly evaluate the therapeutic use of GcMAF.

The main targets of the pharmacologic approaches to COVID-19, especially for the complicated cases, are addressed to modulate the immune system and counteract the overwhelming inflammation.

Notably, the mechanisms we have hypothesized about the possible pathogenesis of the cell and tissue damage induced by SARS-CoV-2 seem to provide a common denominator in explaining the effects of most drugs currently considered for the treatment of COVID-19: these include antivirals (i.e. remdesivir, lopinavir/ritonavir, darunavir, cobicistat) and immunomodulating and/or anti-inflammatory drugs ^[65], [66].

In particular, based on their antiviral activity ^[67], chloroquine and hydroxychloroquine, initially conceived as antimalarial therapeutics, were proposed to treat patients hospitalized with COVID-19, better if associated to azithromycin, showing promising efficacy in “inhibiting the exacerbation of pneumonia, improving lung imaging findings, promoting a virus negative conversion and shortening the disease course“ ^[68], [69]. On the other hand, hydroxychloroquine is the cornerstone of medical therapy in lupus, where it acts as an immunomodulatory without immunosuppressive effects ^[70]. However, in light of ongoing serious cardiac adverse events ^[71] and other serious side effects, the known and potential benefits of chloroquine and hydroxychloroquine no longer outweigh the known and potential risks for the authorized use in COVID-19 patients. In addition, the COVID-19 Treatment Guidelines Panel recommends against using hydroxychloroquine plus azithromycin for the treatment of COVID-19, except in a clinical trial ^[72].

Please watch this video for further explanation on the functions of GcMAF

For more on GCMAF please see this section

Obtaining GcMAF

In the article it mentions different generations of GCMAF as we have seen there have been many imitators and so the sourcing of the correct GcMAF remains essential.

The purest forms of GcMAF and it is essential to purchase it from a reputable company that tests for purity and uses a world class laboratory for the production of pure GCMAF.

This cannot be made from home and must always be purchased and administered through an experienced medical practitioner.

As mentioned in the Saisei Mirai in Japan also distribute clean and reputable GCMAF, however, we have found the best source so far to be Vigor Life in Bulgaria. Feel free to email them directly here: [email protected]

They also have faster shipping methods, with more distribution centres world wide at a slightly lower price and can offer some general advice.

So lets celebrate some good news at last.

We do the research, you decide.

Source: NCBI, Healing Oracle