Fenbendazole / Mebendazole / Benzimidazole are all different names for a fungicide drug that is more commonly associated with treating worms in animals. They are already clinically approved and have been found to possess previously unrecognized cytotoxicity towards malignant cells and as such are great anti-cancer candidates for lung and breast cancer in particular.
It makes sense that a drug that was first introduced for animals is shown to be working for humans too. As mammals we are all genetically very similar and cancer is in itself a fungus, so kill the fungus, kill the cancer.
Fenbendazole is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites including: giardia, roundworms, hookworms, whipworms, the tapeworm genus etc. Mebendazole is in a class of medications called anthelmintics. It works by killing the worms and in turn, both of these drugs can also cause the death of cancer cells.
This drug costs $1 (USD) per day and has better results than chemotherapy and radiotherapy.
It is not load bearing on your vital organs, there is no hair loss, or vomiting associated with it, so no need for other drugs to counteract it. It does not destroy your immune system and NOBODY has ever died from the side effects.
So why are we not using this more, or celebrating it as a break through in cancer research? Is it because it is a far cheaper alternative than the extortionate costs of chemo, radiation and surgery?
These are a softer pharmaceutical drug and is not as harmful to the human body as many of the chemotherapy’s that have been developed for breast and lung cancers, making it a kinder and easier alternative.
Please note that this is not a stand alone treatment and as such is far more effective if taken alongside Immunotherapy (GcMAF) and some other holistic treatments including M Oil and must be accompanied by a good probiotic for the gut.
Clean diet It is also vital that you stick to a clean diet, with no processed foods, refined sugars, dairy, meat and wheat, or anything that sugars in the body, as sugar feeds the fungus that is the cancer in the body. You need to also avoid any food that causes inflammation in the body.
Please see this article for the full information on the best diet for battling cancer and the foods that you can eat. It need not be the end of tasty food.
Please see this Scientific Report for more information on the proven benefits of Febendazole with breast and lung cancer:
Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways
Fenbendazole, FZ, is a Methyl N-(6-phenylsulfanyl-1H benzimidazol-2-yl) carbamate, a benzimidazole compound, is a safe and inexpensive anthelmintic drug possessing an efficient anti-proliferative activity.
In our earlier work, we reported a potent growth-inhibitory activity of FZ caused partially by impairment of proteasomal function. Here, we show that FZ demonstrates moderate affinity for mammalian tubulin and exerts cytotoxicity to human cancer cells at micromolar concentrations.
Simultaneously, it caused mitochondrial translocation of p53 and effectively inhibited glucose uptake, expression of GLUT transporters as well as hexokinase (HK II) – a key glycolytic enzyme that most cancer cells thrive on.
It blocked the growth of human xenografts in nu/nu mice model when mice were fed with the drug orally. The results, in conjunction with our earlier data, suggest that FZ is a new microtubule interfering agent that displays anti-neoplastic activity and may be evaluated as a potential therapeutic agent because of its effect on multiple cellular pathways leading to effective elimination of cancer cells.
The importance of microtubules in cell division, motility, intracellular trafficking and their role in modulating cellular shape according to the environment has made them one of the most successful targets of anticancer therapy. Agents that perturb the microtubule dynamics have been widely used in cancer treatment1,2,3,4. Considering the relative success of mitotic agents in the treatment of cancer, microtubules may be termed as one of the best cancer targets identified till now5.
Fenbendazole (methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl) carbamate) is a broad-spectrum benzimidazole anthelminthic approved for use in numerous animal species7. Repurposing of veterinary drugs showing promising results for human use can result in considerable time and cost reduction required to develop new drugs. Fenbendazole is known to have a high safety margin and most species tolerate it very well. It has very low degree of toxicity and high degree of safety in experimental animals8,9,10,11,12. In this study, we show that fenbendazole (FZ) exhibits a moderate microtubule depolymerizing activity towards human cancer cells, but possesses a potent antitumor effect as evident from in vitro and in vivo experiments. Our results indicate that FZ exerts its antitumor effect through the disruption of microtubule dynamics, p53 activation and the modulation of genes involved in multiple cellular pathways. FZ treatment also resulted in reduced glucose uptake in cancer cells due to down regulation of GLUT transporters and key glycolytic enzymes.
Since the process of tumorigenesis involves a number of genes and proteins altering various cell signaling pathways, single-target drugs show limited efficacy and may lead to drug resistance13,14,15. Agents having multiple cellular targets, therefore, are expected to have improved efficacy besides the ability to circumvent the likelihood of developing resistance.
Overall, the present work demonstrates a pleiotropic effect of FZ on cancer cells leading to cell death. Thus, FZ may have a potential therapeutic application.
Tubulin acetylation has been associated with the stability of microtubules. Therefore, to examine the acetylation status of tubulin following treatment, human NSCLC cells were treated with different microtubule targeting agents for 24 h and the cell extracts were subjected to western blot analysis using Ac-α-tubulin specific antibody (6–11B-1). As shown in Fig. 1e, while nocodazole, colchicine and vincristine resulted in a marked reduction of acetylated tubulin, FZ did not alter the amount of acetylated tubulin as compared with control mock treated cells. This result further confirmed the relatively mild effect of FZ on mammalian tubulin as compared with other known microtubule depolymerizing agents.
Take 200mg Fenbendazole / Mebendazole / Benzimidazole a day for 4 days.
Then have 4 days off the medication.
Repeat the cycle of 4 days on and then 4 days off
This cycle should last 30 days (one month)
Then review your case with a medical professional
How should this medicine be used?
Mebendazole comes as a chewable tablet. When mebendazole (Emverm) is used to treat whipworm, roundworm, and hookworm it is usually taken twice a day, in the morning and evening, for 3 days. When mebendazole (Emverm) is used to treat pinworm, it is usually taken as a single (one-time) dose.
Mebendazole (Vermox) is usually taken as a single (one-time) dose. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take mebendazole exactly as directed. Do not take more or less of it or take it more often than prescribed by your medical practicioner.
If you are taking mebendazole (Emverm) chewable tablets, you may chew the tablets, swallow them whole, or crush and mix them with food.
You should thoroughly chew mebendazole (Vermox) chewable tablets; do not swallow the tablet whole. However, if you cannot chew the tablet, you may place the tablet on a spoon and add a small amount of water (2 to 3 mL) onto the tablet using a dosing syringe. After 2 minutes, the tablet will absorb the water and become a soft mass that should be swallowed.
What special precautions should I follow?
Before taking mebendazole,
tell your doctor and pharmacist if you are allergic to mebendazole, any other medications, or any of the ingredients in mebendazole chewable tablets. Ask your pharmacist for a list of the ingredients.
tell your doctor and pharmacist what other prescription and non-prescription medications, vitamins, nutritional supplements you are taking or plan to take. Be sure to mention any of the following: cimetidine (Tagamet) or metronidazole (Flagyl, in Pylera). Your doctor may need to monitor you carefully for side effects.
tell your doctor if you have or have ever had stomach or liver disease.
tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking mebendazole, call your doctor.
you should know that in addition to your treatment with mebendazole, you will need to take steps to prevent reinfection and infection of other people. You should wash your hands and fingernails with soap often, especially before eating and after using the toilet. Talk to you doctor about other measures to prevent reinfection and spread of the infection to others. Be sure to carefully follow the instructions provided by your doctor.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
Mebendazole may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
stomach pain, discomfort, or swelling
loss of appetite
Some side effects can be serious. If you experience any of these symptoms call your doctor immediately or get emergency medical treatment:
shortness of breath
difficulty breathing or swallowing
fever, sore throat, chills, or other signs of infection
Mebendazole may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
This article is for education purposes only, please consult with a medical professional before taking any medication
We do the research, you decide.
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Article Posted By: Md Fermín Celma Simón
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