Clinical cases presented here reinforce the hypothesis that GcMaf could become part of anticancer immunotherapeutic regimes.

 

 

Abstract Title:

GC protein-derived macrophage-activating factor decreasesα-N-acetylgalactosaminidase levels in advanced cancer patients.

Abstract Source:

Oncoimmunology. 2013 Aug 1 ;2(8):e25769. Epub 2013 Jul 29. PMID: 24179708

Abstract Author(s):

Lynda Thyer, Emma Ward, Rodney Smith, Jacopo Jv Branca, Gabriele Morucci, Massimo Gulisano,  Robert Eslinger, Stefania Pacini

Article Affiliation:

Lynda Thyer

Abstract:

α-N-acetylgalactosaminidase (nagalase) accumulates in the serum of cancer patients and its activity correlates with tumor burden, aggressiveness and clinical disease progression. The administration of GC protein-derived macrophage-activating factor (GcMAF) to cancer patients with elevated levels ofnagalase has been associated with a decrease of serum nagalase activity and with significant clinical benefits. Here, we report the results of the administration of GcMAF to a heterogeneous cohort of patients with histologically diverse, advanced neoplasms, generally considered as”incurable”diseases. In most cases, GcMAF therapy was initiated at late stages of tumor progression. As this is an open-label, non-controlled, retrospective analysis, caution must be employed when establishing cause-effect relationships between the administration GcMAF and disease outcome. However, the response to GcMAF was generally robust and some trends emerged. All patients (n = 20) presented with elevated serum nagalase activity, well above normal values. All patients but one showed a significant decrease of serum nagalase activity upon weekly GcMAF injections. Decreased nagalase activity was associated with improved clinical conditions and no adverse side effects were reported. The observations reported here confirm and extend previous results and pave the way to further studies aimed at assessing the precise role and indications for GcMAF-based anticancer immunotherapy.

About the Author

Amanda-Mary
I am known as Mary which is my middle name. I am a holistic practitioner and Senior Cancer researcher. I can be a gentle woman, I have a big heart and big personality! I'm the caretaker type. When you are on the side of the road with a flat Tyre, I'm the lady who stops, when you need to pull out onto the road, i am the lady that gives way. When you are coming through the door, I'm the lady who holds it for you and gives you a humble smile and a soft hello, I will always give up my seat to others regardless of age, disability or gender. I work hard with my mind and my hands and I am more "in tune" with life, truth and nature, than most people.I am a well educated professional lady , I am a Cool ,respectful, and a comprehensive person, who really does experience love in its full sense.I can seldom be social, and on occasion an outgoing person. I am well balanced in my life. I am a lady of true character who believes in giving people a fair chance.My children are the most important people in my life, although all none dependent, leading busy lives themselves. I am well read and well traveled, I am not materialistic, I have old fashioned views and morals, I can be blunt when it comes to the truth. I don't tolerate fools and thieves lightly. I am earthy and down to earth with a great sense of humor. I am considerate to my surroundings, i have a love of the outdoors and nature in general.I am a cancer researcher ofI am the nurture carer type. I have been a cancer researcher for almost 2 decades. I work at a Cancer Healing Center as a holistic practitioner. I speak truth about what really cures cancer, openly. I speak about how the medical industry is failing us.I get knocked down but I get up again and come back stronger. I am faithful to my own soul, mind and body. I am a harmless flirt. I have few friends but those I have I adore and will do anything for. I am most often described as eccentric and energetic.My Philosophy of life is to live every day like its my last and every night like it was my 1st and this keeps me young, healthy and fit. No regrets! I am young at heart, full of fun.That's me, love and light.

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